Comparative hemostasis: animal models and new hemostasis tests.
Marjory B Brooks, Tracy Stokol, James L Catalfamo
Clinics in laboratory medicine, Vol. 31, No. 1, pp. 139-59, 2011
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Abstract
This article provides an overview of animal model systems to include their strengths and limitations in the study of hemostasis. Specific examples of spontaneous and engineered animal models are described in the context of cell-based hemostasis. The article concludes with a review of the comparative aspects of 3 laboratory assays of cell-based hemostasis: thromboelastography, thrombin generation, and flow cytometric assessment of platelet activation.
Keywords
AnimalsFlow CytometryPlatelet ActivationModels, AnimalHemostasisGenetic EngineeringHematologic TestsThrombelastographyThrombin